dorsal column stimulator vs spinal cord stimulator

#Dorsal column stimulator vs spinal cord stimulator trial#

The device manufacturer was captured by noting any mention of specific manufacturer’s SCS hardware or relationship with a particular manufacturer in the trial entry. Clinical disorder was captured according to the specific condition described in each trial’s entry and subsequently broadly categorized as either “back/extremity pain,” “SCI,” “FBSS,” “neuropathy,” “complex regional pain syndrome,” “neurological disorders,” “cardiac disorders,” “GI/GU disorders,” or “other.” The country of origin was determined according to the country of the responsible party (i.e., the lead center in multicenter studies). Intervention type, trial start date, study completion status, clinical phase, projected subject enrollment, and funding source were recorded as posted in trial entries. to ensure they pertained to SCS, with relevant trials retained for further analysis. Studies were separately screened by authors I.E.H. This search was conducted on January 26, 2020, and included the search terms, “spinal cord stimulation” or “SCS.” Relevant clinical trial entries identified through other sources were also assessed for eligibility. Ī comprehensive search for past and ongoing clinical trials pertaining to SCS was conducted using the publicly available trial registry, ( ). SCS is increasingly being examined for its therapeutic potential across a range of neurological disorders (e.g., Parkinson’s disease), cardiac disorders (e.g., angina pectoris), and gastrointestinal/genitourinary (GI/GU) disorders (e.g., irritable bowel syndrome). SCS is most often employed to relieve intractable back/extremity pain and is commonly indicated for spinal cord injury (SCI), failed back surgery syndrome (FBSS), neuropathy, and complex regional pain syndrome (CRPS). Epidural SCS has become a mainstream procedure that provides a safe and effective drug-free treatment that is adjustable and nonpermanent. Noninvasive SCS consists of stimulating the cord via one of several transcutaneous techniques (e.g., transcutaneous SCS, trans-spinal direct current stimulation, spinal transcutaneous electrical nerve stimulation, and spinal magnetic stimulation). Invasive SCS involves direct stimulation of the dorsal columns using a surgically implanted epidural or intradural device. SCS can be either invasive or noninvasive. Spinal cord stimulation (SCS) is a well-established neuromodulation modality for the treatment of chronic pain.

This overview of SCS-related clinical trials provides a window into future new indications, novel stimulation techniques, and a heightened understanding of the mechanisms of action.

Improvements in the treatment of pain and novel indications for SCS constitute the majority of studies. Conclusions: A large number of clinical trials of SCS are underway. Emphasizing the need to optimize therapeutic outcomes of SCS, one-quarter of trials predominantly focused on the assessment of alternative stimulation parameters such as burst or high-frequency stimulation. The ratio of investigator-sponsored to industry-sponsored trials was 2:1. The majority of SCS trials were US-based (55.7% of studies), but many countries (e.g., Belgium and UK) are becoming increasingly active. The studies spanned >27 different disorders, with almost 20% of trials pertaining to conditions other than chronic pain syndromes. Most trials examined the efficacy of SCS for chronic pain syndromes or new indications, while others assessed different stimulation parameters. 175 trials (82.5%) involved invasive SCS, while the remaining 37 trials (17.5%) used noninvasive forms of spinal stimulation. Results: In total, 212 relevant clinical trials were identified. Specifically, trials were categorized by intervention, trial start date, study completion status, clinical phase, projected subject enrollment, condition, country of origin, device manufacturer, funding source, and study topic. Trials were analyzed to generate a detailed overview of ongoing SCS-related research. Methods: A search was conducted for clinical trials pertaining to SCS using the database. Objective: To assess the state of SCS-related human research by cataloging and summarizing clinical trials that have been recently completed or are currently underway in this field. Ongoing research in this field is critical in order to gain further insights into the mechanisms of SCS, determine its role in new indications, and refine programming techniques for the optimization of therapeutic outcomes. SCS is now being applied more broadly as a possible therapy for a range of indications, including neurological, cardiac, and gastrointestinal disorders. Background: Spinal cord stimulation (SCS) is a neuromodulation technology widely used in the treatment of intractable chronic pain syndromes.

Dorsal column stimulator vs spinal cord stimulator